Table 3. Univariable and multivariable Cox regression analyses of overall survival in the propensity score matching cohort.
| Variables | HR comparison | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P* | |||
| Family history | Yes vs. no | 1.342 (1.010–1.784) | 0.042 | 1.574 (1.171–2.116) | 0.003 | |
| Age | ≤60 vs. >60 years | 1.256 (0.874–1.805) | 0.216 | – | – | |
| Sex | Male vs. female | 1.118 (0.591–2.114) | 0.732 | – | – | |
| Diabetes mellitus | Yes vs. no | 1.307 (0.711–2.404) | 0.387 | – | – | |
| Cigarette smoking | Ever vs. never | 1.125 (0.827–1.531) | 0.453 | – | – | |
| Alcohol drinking | Ever vs. never | 1.197 (0.863–1.660) | 0.280 | – | – | |
| BMI | ≤24.0 vs. >24.0 kg/m2 | 1.201 (0.901–1.462) | 0.105 | – | – | |
| ASA score | ≤2 vs. >2 | 0.973 (0.634–1.492) | 0.900 | – | – | |
| Cirrhosis | Yes vs. no | 2.191 (1.503–3.192) | <0.001 | NS | 0.178 | |
| Portal hypertension | Yes vs. no | 1.433 (1.078–1.904) | 0.013 | 1.661 (1.224–2.254) | 0.001 | |
| Child-Pugh grade | A vs. B | 1.501 (0.992–2.272) | 0.053 | NS | 0.440 | |
| Preoperative HBV viral load | ≤104 vs. >104 copies/mL | 1.667 (1.220–2.277) | 0.001 | 1.660 (1.185–2.326) | 0.003 | |
| Anti-HBV therapy | Yes vs. no | 1.573 (1.052–2.033) | 0.037 | NS | 0.103 | |
| HBeAg (+) | Yes vs. No | 1.281 (0.944–1.738) | 0.112 | – | – | |
| Preoperative AST level | ≤80 vs. >80 U/L | 1.760 (1.254–2.472) | 0.001 | NS | 0.892 | |
| ECOG performance status | 0 vs. 1–2 | 2.035 (1.530–2.707) | <0.001 | NS | 0.588 | |
| Preoperative AFP level | ≤400 vs. >400 μg/L | 1.643 (1.239–2.180) | 0.001 | 1.396 (1.014–1.924) | 0.041 | |
| Largest tumor diameter | ≤5 vs. >5 cm | 2.011 (1.515–2.669) | <0.001 | 1.864 (1.088–3.192) | 0.023 | |
| Tumor number | Solitary vs. multiple | 3.221 (2.354–4.406) | <0.001 | 1.994 (1.178–3.375) | 0.010 | |
| Tumor rupture | Yes vs. no | 2.894 (1.527–5.485) | 0.001 | NS | 0.111 | |
| Macroscopic vascular invasion | Yes vs. no | 7.868 (5.365–11.537) | <0.001 | 4.670 (3.004–7.258) | <0.001 | |
| Microscopic vascular invasion | Yes vs. no | 1.833 (1.370–2.452) | <0.001 | 1.355 (1.036–1.772) | 0.027 | |
| Satellites | Yes vs. no | 3.398 (2.489–4.638) | <0.001 | 2.262 (1.235–4.141) | 0.008 | |
| Tumor differentiation | Well or moderately vs. poorly | 2.174 (1.437–3.289) | <0.001 | 1.894 (1.214–2.955) | 0.005 | |
| Intraoperative blood loss | ≤400 vs. >400 mL | 2.027 (1.524–2.696) | <0.001 | NS | 0.701 | |
| Blood transfusion | Yes vs. no | 2.887 (2.118–3.936) | <0.001 | NS | 0.134 | |
| Extent of hepatectomy | Major vs. minor | 2.583 (1.919–3.476) | <0.001 | NS | 0.129 | |
| Type of resection | Anatomical vs. non-anatomical | 1.073 (0.797–1.446) | 0.642 | – | – | |
*, Those variables found significant at P<0.1 in univariable analyses were entered into multivariable Cox regression models. AFP, alpha-fetoprotein; ASA, American Society of Anesthesiologists; AST, aspartate aminotransferase; BMI, body mass index; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; HR, hazard ratio; NS, not significant.