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. 2018 Aug 6;34(5):783–794. doi: 10.1093/ndt/gfy238

FIGURE 1.

FIGURE 1

Butyrate ameliorates hyperglycemia in 5/6th Nx rats. Butyrate treatment was started 2 weeks after surgery and continued for 6 weeks. (A) Oral GTT: Plasma glucose concentration in response to oral glucose administration. (B) AUC of glucose after oral glucose administration. (C) ITT: The animals were given insulin i.p. and plasma glucose measured by glucometer. (D) AUC of glucose after insulin administration. (E) PTT: Plasma glucose concentration in response to i.p. pyruvate administration. (F) AUC of glucose after pyruvate administration. Data are expressed as mean ± SD (n = 6). Butyrate control consisted of five animals. Statistically significant differences between the groups are given as follows: aP < 0.05 compared with control; bP < 0.01 compared with control; cP < 0.05 compared with butyrate control; dP < 0.01 compared with butyrate control; eP < 0.05 compared with Nx + butyrate; fP < 0.01 compared with Nx + butyrate.