FIGURE 2.

Butyrate increases GLP-1 secretion and reduces plasma LPS levels of 5/6th Nx rats. Butyrate was given for 6 weeks. (A) Blood was collected 8 weeks after surgery. Plasma GLP was measured by enzyme immunoassay 30 min after oral glucose administration (2 g/kg). GLP levels of the Nx group were significantly lower than the control and butyrate control groups. Butyrate treatment significantly abated the decrease. There was no significant difference in the GLP levels of the control, butyrate control and Nx + butyrate groups. (B) Plasma LPS was measured by a Lonza kit. The LPS levels of the Nx group were significantly higher than the control and butyrate control groups. Although butyrate treatment (Nx + butyrate) significantly decreased the LPS levels, it was still significantly higher than the control (P = 0.005) and butyrate control (P = 0.006) groups. Data are mean ± standard deviation of five to six animals per group. Butyrate control consisted of five animals.