Figure 5.

MEX3C activated JNK pathway.(A) GSEA indicates that high expression of MEX3C is associated with the MAPK/JNK signaling pathway in the TCGA bladder cancer databases. (B) Western blot showed that overexpression of MEX3C promoted p-JNK protein level, while total JNK protein level remained unchanged compared with negative control (mean ± SEM, **, p<0.01, t test). (C) A model depicting MEX3C^,s regulation of fatty acid metabolism in bladder cancer. Overexpression of MEX3C increased the protein levels of SREBP-1,FASN and ACC1, and FASN, which activated by MAPK/JNK signaling, leading to tumor progression.

Abbreviations: MEX3C, Mex-3 RNA- Binding Family Member C; GSEA, gene set enrichment analysis; TCGA, The Cancer Genome Atlas; FASN, fatty acid synthase; SREBP1, sterol regulatory element-binding protein-1; ACC1, acetyl-CoA carboxylase-1.