Table 4.
Factors related to AAD in combined administration of antibiotics by univariate and multivariate regression analyses
| Related factors | Univariate regression analysis | Multivariate regression analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age | 1.019 (1.002–1.035) | 0.026 | 1.009 (0.989–1.029) | 0.380 |
| Male | 1.712 (0.837–3.501) | 0.141 | ||
| Use proton pump inhibitors | 2.830 (0.915–8.758) | 0.071 | ||
| Proton pump inhibitors time | 1.127 (1.043–1.218) | 0.003 | 1.142 (1.048–1.244) | 0.002 |
| Parenteral nutrition | 1.650 (0.830–3.281) | 0.153 | ||
| Preventive use of probiotics | 0.802(0.395–1.627) | 0.541 | ||
| Albumin levels | 1.023 (0.975–1.073) | 0.352 | ||
| Hypertension | 2.667 (1.250–5.688) | 0.011 | 1.799 (0.719–4.500) | 0.209 |
| Diabetes | 1.014(0.356–2.892) | 0.979 | ||
| APACHE II score at admission into the ICU | 1.014 (0.967–1.065) | 0.562 | ||
| Creatinine | 1.000 (0.998–1.002) | 0.683 | ||
| Antifungals | 2.688 (1.215–5.948) | 0.015 | 3.189 (1.314–7.740) | 0.010 |
| Cephalosporins | 1.213 (0.583–2.525) | 0.605 | ||
| Carbapenem | 1.076 (0.554–2.088) | 0.830 | ||
| Beta-lactam plus enzyme inhibitorsa | 2.836 (1.284–6.265) | 0.010 | 3.072 (1.309–7.205) | 0.010 |
| Quinolones | 1.886 (0.852–4.174) | 0.118 | ||
| Glycopeptidesb | 1.273 (0.512–3.166) | 0.604 | ||
| Oxazolidinones | 1.622 (0.800–3.289) | 0.180 | ||
| Anti-anaerobic bacteria Antibioticsc | 1.069 (0.429–2.664) | 0.886 | ||
| Azithromycins | 2.603 (0.797–8.506) | 0.113 | ||
Notes: aBeta-lactam plus enzyme inhibitors were piperacillin-tazobactam and sulbactam-cefoperazone. bGlycopeptides were Vancomycin and teicoplanin. cAnti-anaerobic bacteria antibiotics were metronidazole.
Abbreviation: AAD, antibiotic-associated diarrhea.