Table 2.
Univariate and multivariate analyses of prognostic factors for overall survival in non-APL patients
| Prognostic factors | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | |
| Age | 2.433 (1.599–3.702) | <0.001 | 2.088 (1.359–3.207) | 0.001 |
| WBC | 2.118 (1.405–3.193) | <0.001 | 1.000 (0.997–1.002) | 0.804 |
| Karyotype | 1.744 (1.404–2.165) | <0.001 | 1.751 (1.266–2.421) | 0.001 |
| MCL-1 expression | 1.710 (1.125–2.600) | 0.012 | 1.777 (1.164–2.714) | 0.008 |
| FLT3-ITD mutation | 1.403 (0.698–2.822) | 0.342 | - | - |
| NPM1 mutation | 1.484 (0.738–2.982) | 0.268 | - | - |
| CEBPA mutation | 0.818 (0.375–1.783) | 0.613 | - | - |
| c-KIT mutation | 0.613 (0.150–2.503) | 0.496 | - | - |
Notes: Multivariate analyses, including variables [age (>60/≤60 y), WBC (≥30/<30*109/L), MCL-1 expression (high/low), and gene mutations] with P<0.200 in univariate analysis.
Abbreviations: APL, acute promyelocytic leukemia; WBC, white blood cells.