Table 1.

List of eligibility criteria

Inclusion criteria	Exclusion criteria
Age between 50 to 85 years ASA status ≤3 Primary total knee replacement	Contraindication to tranexamic acid Antiplatelet or anticoagulant therapy Coagulopathy disorders (i.e. hepatopathy, hemopathy...) History of thromboembolism Platelet count <150,000 mm3 aPTT ratio and INR >1.20 Serum creatinine >1.5 mg/dL

ASA status = American Society of Anesthesiologists