Fig. 2.

Regulation of metabolism-related factors in hibernating bear muscles. The relative abundance of muscle (vastus lateralis) proteins in winter (hibernating) versus summer (active) brown bears (N = 7 per season) is shown using the following colour code: significantly (Welch student and paired Student tests; P < 0.05) up- and down-regulated proteins are shown in red and green boxes, respectively; black boxes show proteins that did not change, and white boxes show proteins that were not detected (in black letters) or those for which slightly less reproducible up- (in red) or down- (in green) regulation was recorded. FABP3 (in orange) was identified in two distinct protein spots (2D-DIGE strategy) that exhibited opposite responses, suggesting the possible occurrence of post-translational modifications. Detailed protein abundances and fold changes are given in Additional file 1: Table S1 and Additional file 2: Table S2. WAT: white adipose tissue