Fig. 1.

Homologous recombination deficiency scores according to the response to platinum rechallenge. a Telomeric allelic imbalance (tAI); b Loss of heterozygosity score (LOH); c Large scale transition score (LST); d Composite score (CS). Overall response rates according to molecular alterations. e Telomeric allelic imbalance score (tAI) Loss of heterozygosity score (LOH); Large scale transition score (LST) and Composite score (CS); f BRCA mutation; Homologous recombination (HR) gene mutation; CCNE1 copy number gain; CCNE1 copy number gain and RB1 copy number loss