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. 2019 Mar 25;40(18):1411–1422. doi: 10.1093/eurheartj/ehz132

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© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Change in plaque burden, plaque area, and plaque composition according to plaque structural stress. (A and B) Change in plaque area and plaque burden (A) and composition (B) in the entire cohort according to plaque structural stress. (C and D) Change in plaque area and plaque burden (C) and composition (D) in areas of progression according to plaque structural stress. (E and F) Change in plaque area and plaque burden (E) and composition (F) in areas of regression according to plaque structural stress. Data are presented as means ± standard error of mean. Entire cohort (n = 1215). P-values are for high plaque structural stress vs. low plaque structural stress (only statistically significant values are shown). Figures illustrate the results of linear mixed-effects models (Table 2). DC, dense calcium; FF, fibrofatty; FT, fibrous tissue; NC, necrotic core; PA, plaque area; PB, plaque burden; PSS, plaque structural stress.