Table 1.
Characteristics of non-small-cell lung cancer patients with preexisting COPD by COPD subtype
| Covariate | Chronic bronchitis, n (%) | Emphysema, n (%) | No COPD, n (%) | Total, n (%) |
P-value |
|---|---|---|---|---|---|
| No of patients | 11,221 (18.97) | 3,475 (5.87) | 44,466 (75.15) | 59,162 | |
| Sex | 0.45 | ||||
| Males | 5,809 (51.77) | 1,787 (51.42) | 22,715 (51.08) | 30,311 (51.23) | |
| Females | 5,412 (48.23) | 1,688 (48.58) | 21,751 (48.92) | 28,851 (48.76) | |
| Race | <0.0001 | ||||
| White | 10,315 (91.93) | 3,024 (87.02) | 38,447 (86.46) | 51,786 (87.53) | |
| Black | 720 (6.42) | 343 (9.87) | 3,692 (8.30) | 4,755 (8.03) | |
| American Indian | 36 (0.32) | 3 (0.09) | 126 (0.28) | 165 (0.27) | |
| Asian | 137 (1.22) | 96 (2.76) | 2,128 (4.79) | 2,361 (3.99) | |
| Other | 15 (0.13) | 13 (0.37) | 73 (0.16) | 101 (0.17) | |
| Age mean (SD) | 74.73 (6.39) | 74.71 (6.35) | 75.42 (6.94) | <0.0001 | |
| Age group (years) | <0.0001 | ||||
| 66–69 | 2,449 (21.83) | 743 (21.38) | 9,461 (21.28) | 12,653 (21.38) | |
| 70–73 | 2,411 (21.49) | 633 (18.22) | 8,429 (18.96) | 11,473 (19.39) | |
| 74–79 | 3,314 (29.53) | 1,098 (31.60) | 12,389 (27.86) | 16,801 (28.39) | |
| 80+ | 3,047 (27.15) | 1,001 (28.81) | 14,187 (31.91) | 18,235 (30.82) | |
| Comorbidities | |||||
| Myocardial infarction | 410 (3.65) | 143 (4.12) | 1,878 (4.22) | 2,431 | 0.027 |
| Congestive heart failure | 1,527 (13.61) | 344 (9.90) | 3,829 (8.61) | 5,700 | <0.0001 |
| Peripheral vascular disease | 599 (5.34) | 202 (5.81) | 2,014 (4.53) | 2,815 | <0.0001 |
| Cerebrovascular disease | 445 (3.97) | 162 (4.66) | 2,263 (5.09) | 2,870 | <0.0001 |
| Dementia | 104 (0.93) | 27 (0.78) | 650 (1.46) | 781 | <0.0001 |
| Asthma | 278 (2.48) | 110 (3.17) | 1,287 (2.98) | 1,675 | 0.03 |
| Connective tissue disease | 132 (1.18) | 48 (1.38) | 643 (1.45) | 823 | 0.09 |
| Peptic ulcer | 89 (0.79) | 29 (0.83) | 419 (0.94) | 537 | 0.31 |
| Mild liver disease | 81 (0.72) | 29 (0.83) | 529 (1.19) | 639 | <0.0001 |
| Diabetes mellitus | 1,170 (10.43) | 320 (9.21) | 5,207 (11.71) | 6,697 | <0.0001 |
| Diabetes mellitus with complications | 85 (0.76) | 30 (0.86) | 366 (0.82) | 481 | 0.76 |
| Hemiplegia | 49 (0.44) | 18 (0.52) | 373 (0.84) | 440 | <0.0001 |
| Renal disease | 486 (4.33) | 127 (3.65) | 1,713 (3.85) | 2,326 | 0.04 |
| Severe liver disease | 19 (0.17) | 13 (0.37) | 130 (0.29) | 162 | 0.009 |
| Charlson’s comorbidity score | <0.0001 | ||||
| 0 to 2 | 10,676 (95.14) | 3,306 (95.13) | 42,785 (96.22) | 56,787 | |
| 3 to 5 | 529 (4.71) | 155 (4.46) | 1,650 (3.71) | 2,334 | |
| >5 | 16 (0.14) | 14 (0.40) | 31 (0.07) | 61 | |
| Tumor grade | <0.0001 | ||||
| Well differentiated | 340 (3.03) | 147 (4.23) | 1,847 (4.15) | 2,334 | |
| Moderately differentiated | 1,476 (13.15) | 529 (15.22) | 6,122 (13.77) | 8,127 | |
| Poorly differentiated | 2,420 (21.57) | 789 (22.71) | 9,665 (21.74) | 12,874 | |
| Undifferentiated | 567 (5.05) | 182 (5.24) | 2,126 (4.78) | 2,875 | |
| Unknown | 6,418 (57.19) | 1,828 (52.61) | 24,706 (55.80) | 32,952 | |
| Stage (TNM) | <0.0001 | ||||
| Stage I | 2,402 (21.41) | 766 (22.04) | 7,184 (16.16) | 10,352 | |
| Stage II | 539 (4.80) | 171 (4.92) | 2,282 (5.13) | 2,992 | |
| Stage IIIA | 986 (8.79) | 284 (8.17) | 3,417 (7.68) | 4,687 | |
| Stage IIIB | 1,731 (15.43) | 505 (14.53) | 6,680 (15.02) | 8,916 | |
| Stage IV | 4,116 (36.68) | 1,398 (40.23) | 19,675 (44.25) | 25,189 | |
| Unknown | 1,447 (12.90) | 351 (10.10) | 5,228 (11.76) | 7,026 |