Skip to main content
. 2019 May 3;2(5):e193348. doi: 10.1001/jamanetworkopen.2019.3348

Figure 1. Regional Plots of Thyrotoxic Periodic Paralysis Association at 4q31.3, 11q14.1, and 17q24.3.

Figure 1.

A-C, The thyrotoxic periodic paralysis association of 375 single-nucleotide polymorphisms (SNPs) at 4q31.3 (A), 458 SNPs at 11q14.1 (B), and 810 SNPs at 17q24.3 (C) in the genome-wide association studies samples. The color of each genotyped SNP spot reflects its r2, with the top SNP within each association locus shown as a large red diamond and smaller values changing from red to white. Genetic recombination rates, estimated using the 1000 Genomes pilot 1 Han Chinese in Beijing and Japanese in Tokyo data sets, are shown in blue. Physical positions are based on NCBI build 37. D, Linkage disequilibrium block analyses for the 12 tagSNPs at 17q24.3, selecting for genotyping in the replication cohorts.