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. 2019 May 3;2(5):e193348. doi: 10.1001/jamanetworkopen.2019.3348

Figure 2. The Weighted Genetic Risk Score (wGRS) Prediction Models of Thyrotoxic Periodic Paralysis (TPP) in Participants With Graves Disease (GD).

Figure 2.

To predict the potential ratio of TPP seizures in patients with GD, we used the wGRS model to construct the prediction model from 3 and 11 independent single-nucleotide polymorphisms (SNPs) as the markers. The receiver operator characteristic (ROC) curves and the area under the curves (AUCs) of wGRS are shown. A, In 1649 patients with GD and no history of TPP and 491 patients with TPP, the ROC curves of 3 SNPs and 11 SNPs as the markers are shown in navy and blue, respectively, while the reference line is shown in orange. The AUCs of the wGRS model of 3 and 11 SNPs are 0.74 and 0.80, respectively. B and C, The distribution of the wGRS containing 3 SNPs (B) and 11 SNPs (C) in patients with TPP (navy) and with GD having no history of TPP (blue). In wGRS models containing 3 SNPs and 11 SNPs, individuals are classified as having high risk if they had a risk score greater than 4.78 and 12.20, respectively, indicated by the orange solid line. Kdensity indicates kernel density estimation.