Table 1. Description of the Sample Sets in the Current Study.
Genotyping Stage | Genotyped SNPs, No. | Disease Status | Participants, No. | Male, No./Female, No. | Age at Examination, Mean (SD), y |
---|---|---|---|---|---|
Discovery | 2 752 055 | GD with TPP | 175 | 164/11 | 34 (11) |
Control | 2160 | 601/1559 | 45 (9) | ||
GD without TPP | 1519 | 366/1153 | 38 (13) | ||
Replication | 134 | TPP | 362 | 294/68 | 35 (11) |
Control | 1089 | 1047/42 | 48 (12) | ||
Combined | 134 | TPP | 537 | 458/79 | 35 (11) |
Control | 3249 | 1648/1601 | 46 (10) |
Abbreviations: GD, Graves disease; SNP, single-nucleotide polymorphism; TPP, thyrotoxic periodic paralysis.