Table 2.
Variable | Number of patients (%) | Odds ratio (95% CI) | P-value |
---|---|---|---|
Demographic variables | |||
Age at first intervention, years | |||
≤60 | 4/9 (44) | Reference | |
>60 | 20/33 (61) | 1.86 (0.42–8.21) | 0.38 |
Sex | |||
Male | 14/23 (61) | Reference | |
Female | 10/19 (53) | 0.72 (0.21–2.47) | 0.60 |
Diabetes mellitus | |||
No | 19/37 (51) | Reference | |
Yes | 5/5 (100) | 10.44 (0.41–265.7) | 0.15 |
Inflammatory disease | |||
No | 17/30 (57) | Reference | |
Yes | 7/12 (58) | 1.05 (0.27–4.07) | 0.94 |
Malignant disease | |||
No | 20/34 (59) | Reference | |
Yes | 4/8 (50) | 0.71 (0.15–3.32) | 0.66 |
Concurrent medicationsa | |||
Aspirin | |||
No | 23/39 (59) | Reference | |
Yes | 1/3 (33) | 0.42 (0.04–4.75) | 0.48 |
Acetaminophen | |||
No | 23/40 (58) | Reference | |
Yes | 1/2 (50) | 0.75 (0.04–12.77) | 0.83 |
Gabapentin | |||
No | 10/18 (56) | Reference | |
Yes | 14/24 (58) | 1.12 (0.33–3.84) | 0.86 |
Local anesthetic | |||
No | 21/37 (57) | Reference | |
Yes | 3/5 (60) | 1.07 (0.16–7.13) | 0.94 |
Opioid | |||
No | 19/29 (66) | Reference | |
Yes | 5/13 (38) | 0.35 (0.09–1.34) | 0.12 |
SSRI or SNRI | |||
No | 24/40 (60) | Reference | |
Yes | 0/2 (0) | 0.14 (0–5.86) | 0.29 |
Steroid | |||
No | 24/41 (59) | Reference | |
Yes | 0/1 (0) | 0.23 (0–23.01) | 0.53 |
Tricyclic antidepressant | |||
No | 20/36 (56) | Reference | |
Yes | 4/6 (67) | 1.45 (0.24–8.72) | 0.68 |
Symptoms and interventions | |||
Level of ESI | |||
Thoracal | 19/29 (66) | Reference | |
Cervical | 1/2 (50) | 0.54 (0.03–9.54) | 0.76 |
Lumbar | 4/7 (57) | 0.69 (0.13–3.7) | 0.95 |
ESI medication | |||
Steroid only | 11/15 (73) | Reference | |
Steroid + local anesthetic | 13/22 (59) | 0.56 (0.14–2.28) | 0.41 |
Approach of ESI | |||
Interlaminar | 23/37 (62) | Reference | |
Transforaminal | 1/1 (100) | 1.87 (0.02–184.23) | 0.78 |
Location of cutaneous rash | |||
Thoracic | 21/34 (62) | Reference | |
Cervical | 1/1 (100) | 1.89 (0.01–183.7) | 0.58 |
Extremity | 1/2 (50) | 0.63 (0.04–10.93) | 0.92 |
Lumbar | 1/5 (20) | 0.21 (0.03–1.78) | 0.23 |
Note: aNo patients concurrently used nonsteroidal anti-inflammatory drugs.
Abbreviations: ESI, epidural steroid injection; SNRI, serotonin–norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.