Table 2. Estimated Differences in Sleep Duration According to Atopic Dermatitis Disease Activity and Severity^a.

Disease Activity and Severity	Estimated Difference in Sleep Duration (95% CI), min
	Unadjusted	Adjusted
Nighttime sleep durationb,c
Never reported atopic dermatitis	1 [Reference]	1 [Reference]
Overall active atopic dermatitis	−8 (−10 to −6)	0 (−2 to 2)
No problem	−9 (−13 to −6)	1 (−2 to 4)
Mild	−11 (−13 to −9)	1 (−1 to 3)
Quite bad	−7 (−10 to −5)	0 (−2 to 2)
Very bad	−5 (−10 to 0)	−1 (−6 to 3)
Inactive atopic dermatitis	−33 (−35 to −32)	2 (1 to 4)
Total sleep durationd,e
Never reported atopic dermatitis	1 [Reference]	1 [Reference]
Overall active atopic dermatitis	−10 (−13 to −8)	−2 (−4 to 0)
No problem	−15 (−19 to −10)	−2 (−5 to 1)
Mild	−17 (−19 to −14)	−2 (−4 to −1)
Quite bad	−8 (−11 to −5)	−1 (−4 to 1)
Very bad	−3 (−8 to 2)	−3 (−7 to 1)
Inactive atopic dermatitis	−43 (−45 to −42)	−1 (−3 to 0)

^aResults from unadjusted and adjusted multivariable mixed-effects linear regression models examining the association between atopic dermatitis and nighttime and total sleep duration at 8 time points (30, 42, 57, 69, 81, 115, 140, and 186 months) between ages 2 and 16 years. The multivariable model adjusted for potential confounders, including child’s sex, age, race/ethnicity, and comorbid asthma or allergic rhinitis; household smoking exposure; maternal educational level, social class, and age at delivery; crowding index; and financial difficulties score.

^bUnadjusted model with 11 549 individuals; mean (range) of 5.3 (1-8) observations per individual.

^cAdjusted model with 9109 individuals; mean (range) of 5.0 (1-7) observations per individual.

^dUnadjusted model with 11 531 individuals; mean (range) of 5.3 (1-8) observations per individual.

^eAdjusted model with 9101 individuals; mean (range) of 5.0 (1-7) observations per individual.