Fig. 6.

FBXW7 and MOAP1 attenuated miR-92a-3p mediated Wnt/β-catenin activation and mitochondrial inhibition in CRC. a Effect of Mock, miR-92a-3p, miR-92a-3p/FBXW7 treatment on Wnt/β-catenin activation, stemness and EMT markers expression in SW480, SW620 and LOVO cells by western blot assay. b Effect of Mock, miR-92a-3p, miR-92a-3p/FBXW7 transfection on Wnt/β-catenin activation in SW480, SW620 and LOVO cells by laser scanning confocal microscope. c Effect of Mock, FBXW7, NC and siFBXW7 transfection on ubiquitination and degradation of β-catenin in SW480, SW620 and LOVO cells by western blot. d Effect of Mock and FBXW7 transfection on expression of nucleus β-catenin in SW480, SW620 and LOVO cells by western blot assay. e Effect of Mock, FBXW7, NC, and siFBXW7 treatment on expression of β-catenin in SW480, SW620 and LOVO cells by laser scanning confocal microscope. f Effect of Mock, miR-92a-3p, MOAP1 on expression of MOAP1, BAX, cytochrome C, caspase9, caspase3 in in SW480, SW620 and LOVO cells CRC cells treated with 5-FU/L-OHP therapy. g Effect of Mock, miR-92a-3p, MOAP1 on expression of cytochrome C in in SW480, SW620 and LOVO cells cells treated with 5-FU/L-OHP therapy