Table 1. Effective Number of Tests per Washington Heights, Hamilton Heights, Inwood Community Aging Project by Ethnic Groupa.
| Model | Non-Hispanic White Participants | African American Participants | Caribbean Hispanic Participants | Mean Values | ||||
|---|---|---|---|---|---|---|---|---|
| Tests, No. | P Value | Tests, No. | P Value | Tests, No. | P Value | Tests, No. | P Value | |
| Moderate-high effect | 14 075 | 3.55 × 10−6 | 15 745 | 3.17 × 10−6 | 15 713 | 3.18 × 10−6 | 15 178 | 3.29 × 10−6 |
| Loss of function | 1400 | 3.57 × 10−5 | 1578 | 3.17 × 10−5 | 1574 | 3.18 × 10−5 | 1517 | 3.29 × 10−5 |
| Combined annotation dependent depletion score >20 | 9111 | 5.49 × 10−6 | 10 496 | 4.76 × 10−6 | 10 505 | 4.76 × 10−6 | 10 037 | 4.98 × 10−6 |
a
The tests column reports the number of effective test to adjust for multiple testing comparison. The P value column reports the necessary minimum P value to reach gene-wide significance (ie, a P value of .05 divided by the total number of tests).