Table 2.
Summary of ORs in this meta-analysis.
| Locus | No. of studies | Homozygous model |
Heterozygous model |
Dominant model |
Recessive model |
||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| rs2383206 | 6a | GG/AA (fixed-effect model, I2 = 10%, P = 0.35) | AG/AA (fixed-effect model, I2 = 24%, P = 0.25) | AG + GG/AA (fixed-effect model, I2 = 3%, P = 0.40) | GG/AG + AA (fixed-effect model, I2 = 43%, P = 0.12) | ||||
| 1.18 (1.03, 1.34) | 0.01 | 1.06 (0.95, 1.18) | 0.28 | 1.10 (0.99, 1.21) | 0.07 | 1.14 (1.02, 1.27) | 0.02 | ||
| rs2383207 | 3 | AA/GG (fixed-effect model, I2 = 0, P = 0.43) | AG/GG (fixed-effect model, I2 = 0, P = 0.61) | AG + AA/GG (fixed-effect model, I2 = 0, P = 0.49) | AA/AG + GG (fixed-effect model, I2 = 0, P = 0.51) | ||||
| 0.83 (0.71, 0.99) | 0.03 | 0.89 (0.79, 0.99) | 0.03 | 0.87 (0.79, 0.97) | 0.01 | 0.89 (0.76, 1.04) | 0.14 | ||
| rs10757274 | 4 | GG/AA (fixed-effect model, I2 = 0, P = 0.51) | AG/AA (fixed-effect model, I2 = 43%, P = 0.15) | AG + GG/AA (fixed-effect model, I2 = 5%, P = 0.37) | GG/AG + AA (fixed-effect model, I2 = 44%, P = 0.15) | ||||
| 1.18 (1.01, 1.37) | 0.03 | 1.05 (0.93, 1.19) | 0.43 | 1.09 (0.97, 1.23) | 0.15 | 1.15 (1.01, 1.31) | 0.04 | ||
| rs10757278 | 5a | GG/AA (random-effect model, I2 = 55%, P = 0.06) | AG/AA (fixed-effect model, I2 = 39%, P = 0.16) | AG + GG/AA (random-effect model, I2 = 57%, P = 0.06) | GG/AG + AA (random-effect model, I2 = 59%, P = 0.04) | ||||
| 1.18 (0.94, 1.49) | 0.16 | 0.98 (0.87, 1.10) | 0.70 | 1.05 (0.88, 1.25) | 0.60 | 1.17 (0.95, 1.45) | 0.14 | ||
CI: confidence interval; OR: odds ratio.
For rs2383206, rs10757274, and rs10757278, allele A was the major allele. Therefore, the homozygous model was GG versus AA, the heterozygous model was AG versus AA, the dominant model was the sum of AG and GG versus AA, and the recessive model was GG versus the summation of AG and AA. For rs2383207, since allele G accounts for the majority, the homozygous model was AA versus GG, the heterozygous model was AG versus GG, the dominant model was the sum of AG and AA versus GG, and the recessive model was AA versus the summation of AG and GG.
The values given in boldface mean that the ORs were of statistical significance.
Ding et al.6 was a two-stage research, so we divided it into two studies.