Table 1.
Chromosome Regions With More Than 5 Translocations Following Radiation Exposure at Doses of 0.5, 1, 2.5, and 5 Gy (the Number of Translocations Appeared With at least 3 Different Radiation Doses).
| Location | Genea | Diseaseb | Common Cytogenetic Aberrationsb |
|---|---|---|---|
| 9q34 | SET | Myeloid leukemia-associated Wilms’ tumor |
t(6;9)(p23;q34) t(7;9)(q34;q34.3) t(9;22) |
| 9q34.1 | ABL1 | Chronic myelogenous leukemia | |
| NUP214 | Acute myeloid leukemia | ||
| 9q34.3 | NOTCH1 | Neoplastic transformation | |
| 15q21-q22 | B2M | Multiple myeloma | t(15;17) |
| 15q22 | PML | Promyelocytic leukemia | |
| 15q22-q24 | CYP1A1 | Childhood acute lymphoblastic leukemia | |
| 17p13.1 | TP53 (P53) | Li-Fraumeni syndrome Neuroectodermal tumors Medulloblastoma JPAs in children |
Loss of 17p |
aCancer-related genes within the chromosome translocation sites.
bData obtained from the Atlas of Genetics and Cytogenetics in Oncology and Hematology website, Cancer Genetics Web, and NCBI/OMIM.