Table 3.
Number of Translocations That Appeared More Than 4 Times in the Same Chromosomal Region After Exposure to 5-Gy Radiation, Along With the Related Genes and Their Functions.
| Location | Gene | Diseases | Common Cytogenetic Aberrations |
|---|---|---|---|
| 1q21 | MCL1 | Preneoplastic and neoplastic disease Pancreatic cancers |
t(1;14)(q21;q32) t(X;1)(p11;q21) t(1;12)(q25;p13) t(1;11)(q21;q23) |
| AF1Q (MLLT11, RP11-316M1.10) | Leukemia Acute myelomonocytic leukemia |
||
| 1q21-q22 | NTRK1 | ||
| 1q21.3-q22 | CD48 | Lymphoid leukemia Arthritis |
|
| 1q24-q25 | HPC1 | Hereditary prostate cancer | |
| ABL2 | Leukemia | ||
| 3q21-q27 | MME | Acute lymphoblastic leukemia | |
| 3q21-q28 | TERC | Leukemia | |
| 5q13-q14 | XRCC4 | ||
| 10p11.2 | COT | Human cancer | t(10;11) |
| 14q11.2 | TCRD | ATM-deficient thymic lymphoma Acute lymphoblastic leukemia |
t(11;14)(p15;q11) |
| 18p11.2 | MC2R | Adrenocortical neoplasms | t(X;18)(p11.2;q11.2) |