Table 2. Change in Primary Outcome Measures by Cohort Subgrouping Based on a Linear Mixed-Effects Model Following an ITT Frameworka.
| Measure | Analysis Cohort | Mean (SD) Change From Intake to 6-wk Posttest 1 | Regression γ3 | Wald Test P Value | |
|---|---|---|---|---|---|
| γ3 (Treatment Impact) | γ1 (Learning Effect) | ||||
| SRS-II | All participants (ITT) | −1.654 (1.467) | 0.398 (1.113) | −0.275 | .26 |
| Completers | −1.482 (1.575) | 0.362 (1.185) | −0.247 | .35 | |
| EGG | All participants (ITT) | 2.790 (1.460) | 2.541 (1.110) | 0.465 | .05 |
| Completers | 2.498 (1.551) | 2.731 (1.154) | 0.416 | .11 | |
| VABS-II Socialization | All participants (ITT) | 4.584 (1.619) | −1.558 (1.213) | 0.764 | .005b |
| Completers | 5.384 (1.670) | −1.580 (1.214) | 0.897 | .001b | |
| NEPSY-II Affect | All participants (ITT) | 0.099 (0.570) | −0.068 (0.439) | 0.016 | .86 |
| Completers | 0.047 (0.585) | 0.045 (0.447) | 0.008 | .93 | |
Abbreviations: EGG, Emotion Guessing Game; ITT, intention to treat; NEPSY-II, A Developmental Neuropsychological Assessment, Second edition; SRS-II, Social Responsiveness Scale, Second edition, total score; VABS-II, Vineland Adaptive Behavioral Scales, Second edition.
a
The total cohort includes all 71 individuals who started the study. The completers cohort (n = 52) includes 27 treatment and 25 control participants who completed all intake and posttest 1 measures.
b
Statistically significant with Bonferroni correction at P < .0125.