Table 2.
Molecular alterations according to pediatric T-cell Acute Lymphoblastic Leukemia subtypes, Brazil 2015–2017.
| Mature | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Molecular alterations | n/nt (%) | ETP n/nt (%) | Immature n/nt (%) | Early cortical n/nt (%) | Cortical n/nt (%) | Late cortical n/nt (%) | DP n/nt (%) | SP n/nt (%) | DN n/nt (%) |
| STIL-TAL1pos | 49/231 (21.2) | 3/24 (12.5) | 5/33 (15.2) | 2/10(20) | 6/37 (16.2) | 10/44 (22.7) | 11/30 (36.7) | 8/25 (32) | 4/26 (15.4) |
| TLX3pos | 25/245 (10.2) | 2/23 (8.7) | 1/32 (3.1) | 2/11 (18.2) | 4/42 (9.5) | 6/46 (13) | 2/31 (6.5) | 3/29 (10.3) | 5/29 (17.2) |
| NOTCH1mut | 110/231 (47.6) | 10/27 (37) | 13/29 (44.8) | 10/14 (71.4) | 23/39 (59) | 22/43 (51.2) | 12/30 (40) | 8/22 (36.4) | 11/24 (45.8) |
| FBXW7mut | 38/224 (17) | 3/27 (11.1) | 5/30 (16.7) | 3/14 (21.4) | 9/38 (23.7) | 8/43 (18.6) | 4/27 (14.8) | 4/20 (20) | 2/23 (8.7) |
| N/KRASmut | 19/231 (8.2) | 3/27 (11.1) | 3/31 (9.7) | 3/13 (23.1) | 3/38 (7.0) | 0/45 (0)* | 0/28 (0) | 1/24 (4.2) | 6/23 (26.1)** |
| IL7Rmut | 16/225 (7.1) | 0/26 (0) | 1/31 (3.2) | 4/14 (28.6)* | 2/38 (5.3) | 6/42 (14.3) | 2/28 (6.7) | 0/20 (0) | 1/22 (4.5) |
| FLT3mut | 9/222 (4.1) | 6/27 (22.2)*** | 0/28 (0) | 0/14 (0) | 1/38 (2.6) | 2/43 (4.7) | 0/30 (0) | 0/18 (0) | 0/22 (0) |
n. number of cases with alterations; nt, total of cases tested; pos, positive; mut, mutated;
*
p < 0.05;
**
p < 0.01;
***
p < 0.001.