Table 3.
Pediatric T-cell acute lymphoblastic leukemia and overall survival in univariate analysis, 2005-2017, Brazil.
| Variables | pOS % (SE) | Mean* (SE) | 95%CI | p-value |
|---|---|---|---|---|
| AGE (YEARS) | ||||
| <1 | 22.2 (0.19) | 22.0 (9.58) | (3.2–40.8) | 0.036 |
| 1–10 | 66.7 (0.52) | 45.3 (2.23) | (40.9–49.7) | |
| ≥ 10 | 58.3 (0.57) | 40.9 (2.62) | (35.9–46.1) | |
| LYMPH NODE INFILTRATION | ||||
| Yes | 68.8 (0.44) | 45.9 (1.95) | (42.1–49.8) | 0.008 |
| No | 49.2 (0.69) | 36.8 (3.20) | (30.6–43.1) | |
| MEDIASTINAL MASS | ||||
| Yes | 70.8 (0.56) | 47.5 (2.37) | (42.8–52.1) | 0.044 |
| No | 56.7 (0.50) | 40.1 (2.33) | (35.5–44.7) | |
| T-ALL SUBTYPES | ||||
| Immature vs | 78.5 (0.09) | 49.8 (4.10) | (41.8–57.8) | 0.109 |
| Others | 59.5 (0.04) | 41.9 (1.84) | (38.3–45.5) | |
| Mature SP vs | 49.4 (0.13) | 36.8 (5.73) | (25.6–48.1) | 0.194 |
| Others | 63.5 (0.04) | 43.6 (1.77) | (40.2–47.1) | |
| MOLECULAR ALTERATIONS | ||||
| NOTCH1mut/FBXW7mut | 67.6 (0.55) | 46.3 (2.33) | (41.8–50.9) | 0.027 |
| NOTCH1WT/FBXW7WT | 55.3 (0.62) | 37.8 (3.08) | (31.8–43.8) | |
| STIL/TAL1pos | 47.6 (0.90) | 33.6 (4.51) | (24.8–42.5) | 0.006 |
| STIL/TAL1neg | 66.0 (0.47) | 45.4 (2.00) | (41.5–49.3) | |
| MYB amp | 46.7 (0.17) | 31.5 (8.84) | (14.2–48.8) | 0.113 |
| MYBWT | 64.4 (0.51) | 43.7 (2.30) | (39.2–48.2) | |
| Total | 62.0 (0.04) | 42.8 (1.70) | (39.5–46.1) | |
pOS, probability of overall survival; SE, standard error, CI, confidence interval; SP, CD4 and/or CD8 simple positive; mut, mutated; WT, wild type; pos, positive; neg, negative; amp, amplified.
*
mean survival in months.