Table 4.
Associations of urinary bisphenols and glucose levels among all participants (n = 1,841)a.
Bisphenols | FPG | 1 h-PG | 2 h-PG | Sum of PG z-scores | ||||
---|---|---|---|---|---|---|---|---|
b (95% CI) | p | b (95% CI) | p | b (95% CI) | p | b (95% CI) | p | |
BPA | ||||||||
Per-unit increase in ln (SG-adj BPA) | 0.00 (−0.01, 0.01) | 0.95 | −0.02 (−0.05, 0.02) | 0.32 | −0.01 (−0.04, 0.02) | 0.43 | −0.02 (−0.07, 0.03) | 0.42 |
Low | Reference | Reference | Reference | Reference | ||||
Medium | −0.04 (−0.09, 0.01) | 0.12 | −0.05 (−0.22, 0.11) | 0.53 | −0.01 (−0.14, 0.13) | 0.94 | −0.13 (−0.38, 0.13) | 0.34 |
High | 0.01 (−0.04, 0.06) | 0.68 | −0.05 (−0.22, 0.12) | 0.55 | 0.00 (−0.14, 0.14) | 0.99 | −0.02 (−0.28, 0.24) | 0.88 |
p for trend | 0.39 | 0.62 | 0.98 | 0.94 | ||||
BPS | ||||||||
Per–unit increase in ln (SG–adj BPS) | 0.03 (0.01, 0.04) | <0.01* | 0.04 (−0.01, 0.09) | 0.09 | 0.01 (−0.03, 0.05) | 0.54 | 0.07 (−0.00, 0.14) | 0.05 |
Low | Reference | Reference | Reference | Reference | ||||
Medium | 0.03 (−0.02, 0.09) | 0.20 | 0.13 (−0.04, 0.30) | 0.14 | −0.03 (−0.17, 0.11) | 0.70 | 0.12 (−0.14, 0.37) | 0.37 |
High | 0.05 (−0.00, 0.10) | 0.06 | 0.14 (−0.03, 0.31) | 0.10 | 0.01 (−0.12, 0.15) | 0.84 | 0.18 (−0.07, 0.44) | 0.16 |
p for trend | 0.11 | 0.21 | 0.70 | 0.22 | ||||
BPAF | ||||||||
Per–unit increase in ln (SG–adj BPAF) | 0.01 (−0.00, 0.03) | 0.13 | 0.01 (−0.05, 0.08) | 0.66 | 0.00 (−0.05, 0.05) | 0.99 | 0.03 (−0.06, 0.12) | 0.53 |
Low | Reference | Reference | Reference | Reference | ||||
High | 0.05 (0.01, 0.09) | 0.03* | 0.04 (−0.11, 0.18) | 0.64 | 0.05 (−0.07, 0.17) | 0.39 | 0.15 (−0.07, 0.37) | 0.19 |
p for trend | 0.03* | 0.64 | 0.39 | 0.19 | ||||
BPF (n = 776) | ||||||||
Per–unit increase in ln (SG-adj BPF) | 0.01 (−0.01, 0.02) | 0.51 | 0.02 (−0.03, 0.08) | 0.45 | −0.02 (−0.06, 0.03) | 0.42 | 0.01 (−0.08, 0.09) | 0.87 |
Low | Reference | Reference | Reference | Reference | ||||
Medium | 0.01 (−0.08, 0.09) | 0.90 | −0.08 (−0.35, 0.20) | 0.58 | −0.18 (−0.40, 0.04) | 0.12 | −0.20 (−0.60, 0.21) | 0.34 |
High | 0.01 (−0.08, 0.10) | 0.89 | −0.07 (−0.34, 0.21) | 0.64 | −0.20 (−0.42, 0.02) | 0.08 | −0.18 (−0.59, 0.23) | 0.38 |
p for trend | 0.93 | 0.80 | 0.22 | 0.60 |
SG, specific gravity; FPG, fasting plasma glucose; PG, plasma glucose.
Adjusted for maternal age, pre-pregnancy BMI, educational levels, parity, passive smoking and fetal sex.
Significant p-value.