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(A–D) High G protein-coupled estrogen receptor (GPER) DNA methylation in gastric cancer and GPER methylation were negatively associated with GPER expression. (A) Levels of GPER DNA methylation were much higher in gastric cancer samples than that in normal samples (P<0.005). (B) GPER DNA promoter methylation was inversely associated with the expression of GPER mRNA (Spearman’s r, −0.611).
