Table 3.
Cox regression of G protein-coupled estrogen receptor (GPER) protein expression and overall survival of patients with gastric cancer.
| Clinical factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| P-value | HR (95% CI) | P-value | HR (95% CI) | |
| Gender (Male vs. Female) | 0.736 | 0.859 (0.349–2.103) | – | – |
| Age (≤60 vs. >60) | 0.349 | 1.538 (0.572–4,138) | – | – |
| T stage (T1–T2 vs. T3–T4) | 0.045* | 7.785 (1.042–58.08) | 0.24 | 3.981 (0.398–39.801) |
| N stage (N0 vs. N1–N3) | 0.05 | 2.973 (1.001–8.832) | – | – |
| M stage (M0 vs. M1) | 0.024* | 2.669 (1.135–6.278) | 0.77 | 0.854 (0.296–2.463) |
| Grade (G) (G1 vs. G2–G3) | 0.172 | 1.874 (0.761–4.614) | – | – |
| TNM stage (I–II vs. III–IV) | 0.006* | 5.434 (1.607–18.38) | 0.162 | 2.973 (0.644–13.718) |
| Tumor diameter (≤5 cm vs. >5 cm) | 0.491 | 0.995 (0.413–2.399) | – | – |
| GPER expression (low vs. high) | 0.026* | 0.29 (0.098–0.863) | 0.035* | 0.277 (0.084–0.916) |
*
P<0.05.