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. Author manuscript; available in PMC: 2019 May 7.
Published in final edited form as: Hypertens Res. 2018 Apr 13;41(7):489–498. doi: 10.1038/s41440-018-0041-5

Figure 1. Effect of etamicastat on blood pressure in anesthetized and conscious D2+/+ and D2−/−mice.

Figure 1.

A. Etamicastat (Etam, 1O mg/kg) or vehicle was administered by gavage. Blood pressure was measured under pentobarbital anesthesia 9 and 18 h after etamicastat administration in different groups of D2+/+ and D2−/− mice. n=4–5/group; *P<O.O5 vs all others, one-way ANOVA followed by Holm-Sidak test

B. Etamicastat (Etam, 1O mg/kg/day) or vehicle was added to the drinking water. Blood pressure was measured by telemetry in conscious mice. Values are means of 6 h measurements (one per h). D2+/+ n=5; D2−/− n=4. *P<O.O5 vs D2+/+ one-way ANOVA followed by Holm-Sidak test.

C. Etamicastat (1O or 5O mg/kg/day) was added to the drinking water. Blood pressure was measured by telemetry in conscious mice. Values shown are means of 6 hr measurements during the day and night (one reading per h after 5 days on each treatment). D2+/+ n=4; D2−/− n=3. * P<O.O5 vs D2−/− vehicle or same treatment D2+/+, two-way ANOVA followed by Holm-Sidak test.