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. Author manuscript; available in PMC: 2019 May 7.
Published in final edited form as: Hypertens Res. 2018 Apr 13;41(7):489–498. doi: 10.1038/s41440-018-0041-5

Figure 2. Effect of etamicastat on blood pressure in mice with renal-selective silencing of the D2R.

Figure 2.

Renal cortical Drd2 was silenced by the renal subcapsular infusion of Drd2 siRNA, via an osmotic minipump for seven days in uninephrectomized adult male C57BL/6J mice (see Methods). Etamicastat (Etam, 1O mg/kg/day in the drinking water) was started immediately after pump implantation. Blood pressure was measured under anesthesia before and 7 days after pump implantation. n=5/group; *P<O.O5 vs all others; one-way ANOVA followed by Holm-Sidak test. Two-way ANOVA positive for effect of D2R siRNA and etamicastat.