Table 1. Survival parameters in female WT FVB/N and K14/IGF1 mice.
WT FVB/N (N0 = 69) |
K14/mIGF1 (N0 = 46) |
Difference | ||
Maximum lifespan, days | 993 | 770 | –22.5% | |
Median lifespan, days | 683 | 484 | –29% | |
Mean lifespan, days (mean±SD) | All | 622±227 | 469±156 | –25%, p<0.01 |
The last 10% survivors | 921±36 | 714±35 | –22%, p<0.01 | |
Initial mortality μ0, days–1 (95% CI) |
0.00014 (0.00011; 0.00016) |
0.00013 (0.00009; 0.00017) |
0% | |
Aging rate γ, days–1 (95% CI) |
0.0049 (0.0046; 0.0052) |
0.0077 (0.0069; 0.0084)* |
+57%, p<0.05 |