Figure 6.

UA derivatives impair ookinete development in P. berghei cultured in vitro. (a) Three-dimensioinal surface plots showing variation in GFP fluorescence intensity associated with a dose of BT122. (b) Relationship between dose of BT37 and the mean number of fluorescing parasites distinguished by shape (ookinetes or round cells). To be conservative, shape parameters for the ookinete category were optimized to capture retorts and immature ookinetes since development was not fully impaired in these parasites. Means and standard errors were calculated from counts of four replicates per concentration. (c) Same as panel b for BT122.