Table 4. Summary of clinical outcomes of studies of Vortioxetine.

Lu=LuA21004

Studies	Clinical outcomes
Alvarez E, et al., 2012 [25]	Lu helped with depression, anxiety, and global functioning compared to placebo.
Baldwin DS, et al., 2012 [23]	Lu and duloxetine helped with depression but it failed to reach statistical significance compared to placebo.
Boulenger JP, et al., 2012 [30]	Lu helped with relapse of depression compared to placebo.
Jain R, et al., 2013 [31]	The was no significant difference in symptoms of depression at week 6 compared to placebo.
Mahableshwarkar AR, et al., 2013 [33]	Vortioxetine 2.5 and 5 mg helped with depression compared to placebo but it was not statistically significant.
Boulenger JP, et al., 2014 [27]	Lu and duloxetine resulted in an improvement in depression and anxiety compared to placebo.
Montgomery SA, et al., 2014 [3]	Vortioxetine was significantly superior to placebo for depression, anxiety and global functioning.
Chen G, et al., 2015 [26]	Vortioxetine had no effect on the steady-state pharmacokinetics of aspirin and warfarin.
Jacobsen PL, et al., 2015 [28]	Vortioxetine 20 mg was significantly superior to placebo for depression compared to placebo.
Mahableshwarkar AR, et al., 2015 [29]	Vortioxetine 20 mg helped with depression and anxiety.
Alam MY, et al., 2014 [34]	Participants taking vortioxetine experienced improvement in depression and anxiety symptoms.