Skip to main content
NCBI home page
Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1990 Jun-Jul;81(6-7):550–553. doi: 10.1111/j.1349-7006.1990.tb02605.x

Prevalence of Antibody against Non‐A, non‐B Hepatitis Virus in Japanese Patients with Hepatocellular Carcinoma

Showgo Ohkoshi 1, Hideo Kojima 1, Hironobu Tawaraya 1, Tohru Miyajima 1, Tomoteru Kamimura 1, Hitoshi Asakura 1, Akira Satoh 2, Shinichi Hirose 3, Makoto Hijikata 4, Nobuyuki Kato 4, Kunitada Shimotohno 4,✉
PMCID: PMC6504047  PMID: 2169469

Abstract

Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)‐negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg‐positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg‐negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody‐positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti‐HCV antibody and HBsAg‐negative hepatocellular carcinoma in Japan.

Keywords: Non‐A, non‐B hepatitis virus; Hepatocellular carcinoma; Hepatitis C virus; Antibody

Full Text

The Full Text of this article is available as a PDF (221.6 KB).

REFERENCES

  • 1. ) Perkin , D. M. , Stjernsward , J. and Muir , C. S. Estimates of the worldwide frequency of twelve major cancers . Bull. WHO , 62 , 163 – 182 ( 1984. ). [PMC free article] [PubMed] [Google Scholar]
  • 2. ) The Bureau of Vital Statistics, Ministry of Health and Welfare . The number of cancer deaths and age‐specific cancer mortality rates by site in Japan in 1987 . Jpn. J. Clin. Oncol. , 19 , 181 – 193 ( 1989. ). [PubMed] [Google Scholar]
  • 3. ) Szmuness , W. Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association . Prog. Med. Virol , 24 , 40 – 69 ( 1978. ). [PubMed] [Google Scholar]
  • 4. ) Obata , H. , Hayashi , N. , Motoike , Y. , Hisamatu , T. , Okuda , H. , Kobayashi , S. and Nishioka , K. A prospective study on the development of hepatocellular carcinoma from liver cirrhosis with persistent hepatitis B virus infection . Int. J. Cancer , 25 , 741 – 747 ( 1980. ). [DOI] [PubMed] [Google Scholar]
  • 5. ) Beasley , R. P. , Hwang , L. Y. , Lin , C. C. and Chien , C. S. Hepatocellular carcinoma and hepatitis B virus . Lancet , ii , 1129 – 1133 ( 1981. ). [DOI] [PubMed] [Google Scholar]
  • 6. ) Kiyosawa , K. , Akahane , Y. , Nagata , A. and Furuta , S. Hepatocellular carcinoma after non‐A, non‐B post‐transfusion hepatitis . Am. J. Gastroenterol , 79 , 777 – 781 ( 1987. ). [PubMed] [Google Scholar]
  • 7. ) Okuda , K. , Fujimoto , I. , Hanai , A. and Urano , Y. Changing incidence of hepatocellular carcinoma in Japan . Cancer Res. , 47 , 4967 – 4972 ( 1987. ). [PubMed] [Google Scholar]
  • 8. ) Sakamoto , M. , Hirohashi , S. , Tsuda , H. , Ino , Y. , Shimosato , Y. , Yamasaki , S. , Makuuchi , M. , Hasegawa , H. , Terada , M. and Hosoda , Y. Increasing incidence of hepatocellular carcinoma possibly associated with non‐A, non‐B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases . Cancer Res. , 48 , 7294 – 7297 ( 1988. ). [PubMed] [Google Scholar]
  • 9. ) Okuda , H. , Obata , H. , Motoike , Y. and Hisamitsu , T. Clinicopathological features of hepatocellular carcinoma — comparison of hepatitis B seropositive and seronegative patients . Hepatogastroenterology , 31 , 64 – 68 ( 1984. ). [PubMed] [Google Scholar]
  • 10. ) Dienstag , J. L. Non‐A, non‐B hepatitis, I: recognition, epidemiology and clinical features . Gastroenterology , 85 , 439 – 462 ( 1983. ). [PubMed] [Google Scholar]
  • 11. ) Choo , Q‐I. , Kuo , G. , Weiner , A. J. , Overby , L. R. , Bradley , D. W. and Houghton , M. Isolation of a cDNA clone derived from a blood‐borne non‐A, non‐B viral hepatitis genome . Science , 244 , 359 – 362 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 12. ) Kuo , G. , Choo , Q‐L. , Alter , H. J. , Gitnick , G. L. , Redeker , A. G. , Purcell , R. H. , Miyamura , T. , Dienstag , J. L. , Alter , M. J. , Stevens , C. E. , Tegtmeier , G. E. , Bonino , F. , Colombo , M. , Lee , W‐S. , Kuo , C. , Berger , K. , Shuster , J. R. , Overby , L. R. , Bradley , D. W. and Houghton , M. An assay for circulating antibodies to a major etiologic virus of human non‐A, non‐B hepatitis . Science , 244 , 362 – 364 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 13. ) Nishioka , K. and Japanese Government non‐A, non‐B hepatitis research group. Accomplishments in the past decade and prospects for the next decade: problems solved and problems unsolved . Abstr. 10th Joint Meet. US-Japan Hepatitis Panel , 36 ( 1989. ). [Google Scholar]
  • 14. ) Esteban , J. I. , Esteban , R. , Viladomiu , L. , Lopez‐Talavera , J. C. , Genzalez , A. , Hernandez , J. M. , Roget , M. , Vargas , V. , Genesca , J. and Buti , M. Hepatitis C. virus antibodies among risk groups in Spain . Lancet , ii , 294 – 296 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 15. ) van der Poel , C. L. , Reesink , H. W. , Lelie , P. N. , Leentraar‐Kuypers , A. , Choo , Q‐L. , Kuo , G. and Houghton , M. Anti‐hepatitis C antibodies and non‐A, non‐B post‐transfusion hepatitis in the Netherlands . Lancet , ii , 297 – 298 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 16. ) Kuhnl , P. , Slidl , S. , Stangel , W. , Beyer , J , Sibrowski , W. and Flik , J. Antibody to hepatitis C virus in German blood donors . Lancet , ii , 324 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 17. ) Mortimer , P. P. , Cohen , B. J. , Litton , P. A. , Vandewelde , E. M. , Bassendine , M. F. , Brind , A. M. and Hambling , M. H. Hepatitis C virus antibody . Lancet , ii , 798 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 18. ) Bruix , J. , Barrera , J. M. , Calvet , X. , Ercilla , G. , Costa , J. , Sanchez‐Tapias , J. M. , Ventura , M. , Vall , M. , Brugnera , M. , Bru , C. , Castillo , R. and Rodes , J. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellularcarcinoma and hepatic cirrhosis . Lancet , ii , 1004 – 1006 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 19. ) Colombo , M. , Kuo , G. , Choo , Q‐L. , Donato , M. F. , Ninno , E. D. , Tommasini , M. A. , Dioguardi , N. and Houghton , M. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma . Lancet , ii , 1006 – 1008 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 20. ) Kiyosawa , K. , Tanaka , E. , Sodeyama , K. , Gibo , Y. , Nakano , Y. , Hayada , T. , Furuta , K. , Usuda , S. , Shirnizu , S. , Seki , K. , Nakatsuji , Y. , Furuta , S. , Watanabe , J. and Nishioka , K. Detection of anti‐hepatitis C virus antibody (HCV antibody) using “ORTHO HCV antibody ELISA test system” in patients with various liver diseases and its clinical significance . Igaku to Yakugaku , 22 , 607 – 612 ( 1989. ) ( in Japanese ). [Google Scholar]
  • 21. ) Kato , N. , Ohkoshi , S. and Shimotohno , K. Japanese isolates of non‐A, non‐B hepatitis viral genome show the sequence variation from the original isolates in the USA . Proc. Jpn. Acad. , 65B , 219 – 223 ( 1989. ). [Google Scholar]

Articles from Japanese Journal of Cancer Research : Gann are provided here courtesy of Wiley

RESOURCES