Fig 4. Radiomic heat map.

Unsupervised clustering of patients based on the Stable features (COV≤5%) on the y axis (n = 140) and the radiomic feature expression patterns separately within the Stable (n = 200) and Unstable groups (n = 641) on the x axis. Clinical parameters for the patients are also illustrated at the bottom. For gender, 0 = male and 1 = female; for race (ethnicity), 0 = Caucasian, 1 = African-American, and 2 = others; for pack-year, the patients were divided into 4 quartiles and 0–3 represent the quartiles from low to high; for histology, 0 = adenocarcinoma, 1 = squamous cell carcinoma, and 2 = non-small cell not otherwise classified pathologically; for tumor location (site), 0 = right upper lobe, 1 = right middle lobe, 2 = right lower lobe, 3 = left upper lobe, 4 = left lower lobe, and 5 = chest wall.