Table 1. Single neuron parameter sets.

In the heterogeneous condition, three neuronal types have the values of the described parameters randomly drawn from a normal ($\mathcal{N}$) or lognormal ($\text{log}\mathcal{N}$) distribution. The parameter values for these distributions were determined taking into account multiple sources of experimental data (see S1 Appendix). Note that, to make comparisons simpler, the values displayed for the lognormal distributions correspond to the mean and standard deviation of the distribution, not the actual μ and σ parameters (see Materials and methods).

Parameter	Homogeneous			Heterogeneous			Description
	E	I1	I2	E	I1	I2
Eleak[mV]	−76.43	−64.33	−61	$\mathcal{N}(-73,4)$	$\mathcal{N}(-67.5,2)$	$\mathcal{N}(-62.6,2)$	resting membrane potential
Vthresh[mV]	−44.45	−38.97	−34.44	$\mathcal{N}(-42,4)$	$\mathcal{N}(-40,4)$	$\mathcal{N}(-36,2)$	spike threshold
Vreset[mV]	−54.18	−57.47	−47.11	$\mathcal{N}(-52,5)$	$\mathcal{N}(-58,6.4)$	$\mathcal{N}(-54,5.4)$	reset potential
Gleak[nS]	4.64	9.75	4.61	$\mathcal{N}(4.73,0.38)$	$\mathcal{N}(9.09,0.75)$	$\mathcal{N}(4.5,0.2)$	leak conductance
Cm[pF]	116.52	104.52	102.87	$\mathcal{N}(114,8.7)$	$\text{log}\mathcal{N}(68.9,35.6)$	$\text{log}\mathcal{N}(82.24,17.7)$	membrane capacitance
tref[ms]	2.05	0.52	1.34	$\text{log}\mathcal{N}(1.8,0.25)$	$\text{log}\mathcal{N}(0.5,0.01)$	$\text{log}\mathcal{N}(1.3,0.05)$	absolute refractory time
τm[ms]	25.11	10.72	22.33	$\text{log}\mathcal{N}(22,2)$	$\text{log}\mathcal{N}(9.5,2)$	$\text{log}\mathcal{N}(20,2)$	membrane time constant
Rm[MΩ]	215.54	102.53	217.10	$\text{log}\mathcal{N}(160,50)$	$\text{log}\mathcal{N}(100,10)$	$\text{log}\mathcal{N}(210,10)$	input resistance