Table 3. DRB1 risk and protective residues for specific autoantibodies.
Significant positions map overwhelmingly to Class II proteins, primarily DRB1 for nRNP, Ro/La and cardiolipin, and DPB1 for Sm. Positions with significant association have the most-risk and most-protective amino acids shown. Residues written as: position, amino acid, position in binding pocket, P-value for the Korean and Han Chinese samples, odds ratio. Side-chains predicted risk include: F, L, D. R and S are predicted to be protective. Residues are formatted according to their consistency with the statistical SLE risk-prediction model: risk (bold); protective (italics); and neither (unformatted).
| Antibody | Fraction Class II | Interacting | Significant risk/protection |
|---|---|---|---|
| nRNP | P<1 x10-3: 27/27 | DRB1: P<1 x10-4: 7/8 | 30G (p7; 6 x10-6, 1.71) |
| 30H (p7; 7x10-4, 0.55) | |||
| 11D (p6; 6x10-6, 1.7) | |||
| 11S (p6; 2x10-6, 0.68) | |||
| 13F (p4/6; 6x10-7, 1.65) | |||
| 13S (p4/6; 4x10-4, 0.69) | |||
| Ro/La | P<5 x10-3: 11/11 | DRB1: P<5 x10-3: 5/5 | 13G (p4/6; 8x10-3, 1.48) |
| 13F (p4/6; 7x10-4, 0.61) | |||
| 70D (p4; 5x10-2, 1.24) | |||
| 70R (p4; 7x10-4, 0.62) | |||
| Cardiolipin (ACL) | P<5 x10-3: 14/14 | DRB1: P<1 x10-3: 3/3 | 11D (p6; 8x10-3, 1.69) |
| 11V (p6; 1x10-4, 0.44) | |||
| Sm | P<1 x10-2: 14/18 | DPB1: P<1 x10-3: 3/3 | 11L (p4; 1x10-4, 1.52) |
| 11G (p4; 1x10-4, 0.66) |