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. 2019 Apr 11;216(5):1091–1107. doi: 10.1084/jem.20181618

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© 2019 Broggi et al.

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Figure 4. — Lymph-derived EVs are enriched in tumor-related proteins that may differentiate LAN^neg from LAN^pos melanoma patients. (A and B) Unbiased heat map highlighting the averaged protein concentration profiles (A) and expression profiles of melanoma-associated proteins (B; specified in Table S1) from lymph-derived EVs (L-EV) versus whole lymphatic exudate (L). (C–F) Proteomic profile comparisons using IPA. (C) Activation z-scores for the pathways up-regulated (orange, z-score >2) or down-regulated (blue, z-score < −2) in the lymphatic exudate EVs of LAN^neg versus LAN^pos patients. (D) Top up-regulated pathways in LAN^neg versus LAN^pos lymphatic exudate EVs. ECM, extracellular matrix. (E and F) Top down-regulated (E) or top up-regulated (F) pathways in LAN^pos versus LAN^neg lymphatic exudate EVs. n = 6 for LAN^neg and n = 11 for LAN^pos. Rho GDI, Rho GDP dissociation inhibitor. Raw data in Table S1.