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. 2019 Mar 27;216(5):1027–1037. doi: 10.1084/jem.20181430

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© 2019 Yamano et al.

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Figure 4. — Aire orchestrates a distinct genetic program in Aire⁺ ILC3-like cells. (A) RNA-seq data from Lin^–MHCII^hiCD80⁺ cells from Aire^+/+ and Aire^−/− mice. Genes encoding for TRAs are colored in red. Fold-change cutoff: 1.5; P value: 0.05 (indicated by a dashed line). (B) Quantitative PCR analysis of mRNA expression of selected differentially expressed genes. Data are mean ± SD of three independent experiments. ns, not significant. (C) Comparison of Aire-dependent gene expression in Aire⁺ LN cells and mTECs. Genes that are up-regulated (depicted in red; 1,732 genes) or down-regulated (depicted in blue; 423 genes) by Aire in mTECs by at least 1.5-fold were projected onto the volcano plot shown in A. Student’s t test was used to calculate P values.