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. 2019 Jan 31;151(5):645–659. doi: 10.1085/jgp.201812200

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© 2019 Robinett et al.

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Figure 9. — Schematic of PKA-induced phosphorylation of sMyBP-C. Unphosphorylated sMyBP-C (top) binds both actin and myosin and attenuates the rate and force of contraction as well as impedes filament shortening. The phosphorylation of sMyBP-C (bottom) alleviates its linkage between the thin and thick filament, which enhances the rate and magnitude of force and speeds filament sliding.