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. 2019 Jan 2;151(5):635–644. doi: 10.1085/jgp.201812183

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© 2019 Reda et al.

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Figure 3. — SL dependency of tension cost and c in young and adult guinea pig cardiac muscle preparations. Tension cost was derived as the slope of the linear relationship between steady state tension and ATPase measurements at various pCa (de Tombe and Stienen, 1995; Stienen et al., 1995). The value of c was estimated by fitting the NLRD model to the family of muscle-elicited force responses to various amplitude step-like ML perturbations at pCa 4.3 (Ford et al., 2010). (A and B) Bar graphs showing the SL-dependent effect on tension cost (A) and c (B) in young and adult muscle preparations. Two-way ANOVA revealed that the main effect of SL was significant for both tension cost (P < 0.001) and c (P < 0.001). The main effect of MHC was significant for both tension cost (P < 0.001) and c (P < 0.001). Post hoc multiple comparisons (Holm–Sidak method) were used to determine significant differences between groups. Asterisks and hash marks indicate a significant difference when compared with data within each group (***, P < 0.001 for 1.9 vs. 2.3 µm; ###, P < 0.001 for young vs. adult). The number of preparations measured for all groups was 10. Data are expressed as means ± SEM.