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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: J Immunol. 2019 Apr 15;202(10):3020–3032. doi: 10.4049/jimmunol.1801456

Figure 7.

Figure 7.

IL-1 Drives G-CSF Production and Progenitor Expansion after Injury. A. WT mice were treated with recombinant IL-1RA 1 hour before polytrauma; plasma G-CSF was measured by CBA. B, C. WT mice were treated with 3 doses of IL-1 RA (16 hours before injury, at the time of injury and 8 hours after injury). Bone marrow was harvested 24 hours after injury and analyzed by flow cytometry. B. Representative FACS plots showing progenitors in mice with and without IL-1RA. C. Frequency of LT-HSC, ST-HSC and MPP populations. *=p<0.05 by Mann-Whitney U Test. Data are pooled from 2–3 independent experiments. Individual values shown, horizontal bar/whisker represent mean+/−SD)