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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Curr Biol. 2019 Apr 25;29(9):1460–1470.e4. doi: 10.1016/j.cub.2019.03.066

Figure 7. FzlA is required for activation of FtsWI and regulates the geometry of PG insertion.

Figure 7.

FzlA is required for activation of FtsWI and likely signals (solid arrow) through unidentified intermediate factor(s), possibly via its C-terminus, in a manner dependent on interaction with FtsZ to effect normal cell shape, normal constriction rate, and antibiotic resistance (left). FzlA may also or alternatively contribute to cell wall synthesis activation by influencing FtsZ dynamics (dashed arrow, left). FtsW**I* can still receive input from FzlA (either through signaling, influence of FtsZ dynamics or some combination of both), which in addition to its own hyperactivity, leads to faster constriction and antibiotic sensitivity likely associated with positive misregulation of PG insertion (middle). FtsW**I* can function in the absence of FzlA, but with misregulated activity, leading to twisting during constriction, slower constriction speed, and increased antibiotic sensitivity (right).