Table E3.
Nasopharyngeal microbiota of infants hospitalized for bronchiolitis by respiratory virus category
| Characteristic | RV |
P value | |||
|---|---|---|---|---|---|
| RSV-only (n = 580) | RV-A (n = 91) | RV-B (n = 12) | RV-C (n = 91) | ||
| Richness | |||||
| No. of genera, median (IQR) | 17 (10-25) | 13 (7-23) | 14 (7-24) | 15 (8-22) | .10 |
| Alpha-diversity | |||||
| Shannon index, median (IQR) | 0.96 (0.58-1.49) | 0.94 (0.41-1.39) | 0.67 (0.14-1.34) | 0.91 (0.57-1.28) | .20 |
| Microbiota profiles | <.001 | ||||
| Haemophilus-dominant profile | 83 (14.3) | 30 (33.0) | 3 (25.0) | 17 (18.7) | |
| Moraxella-dominant profile | 119 (20.5) | 17 (18.7) | 4 (33.3) | 27 (29.7) | |
| Mixed profile | 176 (30.3) | 31 (34.1) | 4 (33.3) | 28 (30.8) | |
| Streptococcus-dominant profile | 202 (34.8) | 13 (14.3) | 1 (8.3) | 19 (20.9) | |
| Relative abundance of 10 most abundant genera, mean ± SD | |||||
| Streptococcus | 0.35 ± 0.31 | 0.23 ± 0.26 | 0.17 ± 0.25 | 0.29 ± 0.30 | .002∗ |
| Moraxella | 0.27 ± 0.33 | 0.31 ± 0.33 | 0.42 ± 0.42 | 0.36 ± 0.36 | .10∗ |
| Haemophilus | 0.16 ± 0.28 | 0.30 ± 0.36 | 0.29 ± 0.39 | 0.19 ± 0.29 | .002∗ |
| Prevotella | 0.03 ± 0.07 | 0.02 ± 0.06 | 0.01 ± 0.01 | 0.02 ± 0.06 | .77∗ |
| Neisseria | 0.02 ± 0.07 | 0.02 ± 0.07 | 0.02 ± 0.04 | 0.02 ± 0.10 | .99∗ |
| Staphylococcus | 0.03 ± 0.10 | 0.01 ± 0.07 | 0.01 ± 0.02 | 0.02 ± 0.08 | .72∗ |
| Corynebacterium | 0.02 ± 0.08 | 0.00 ± 0.01 | 0.00 ± 0.01 | 0.00 ± 0.02 | .10∗ |
| Alloprevotella | 0.01 ± 0.05 | 0.02 ± 0.06 | 0.00 ± 0.01 | 0.01 ± 0.06 | .75∗ |
| Veillonella | 0.01 ± 0.03 | 0.01 ± 0.02 | 0.00 ± 0.00 | 0.01 ± 0.02 | .17∗ |
| Gemella | 0.01 ± 0.04 | 0.01 ± 0.02 | 0.00 ± 0.00 | 0.01 ± 0.02 | .61∗ |
IQR, Interquartile range.
∗
Benjamini-Hochberg false-discovery rate–adjusted P value accounting for multiple comparisons.