Table E4.
Characteristics of 774 infants hospitalized for bronchiolitis by nasopharyngeal microbiota profiles
| Characteristic | Microbiota profile |
P value | |||
|---|---|---|---|---|---|
| Haemophilus-dominant (n = 133) | Moraxella-dominant (n = 167) | Mixed profile (n = 239) | Streptococcus-dominant (n = 235) | ||
| Age (mo), median (IQR) | 3.9 (2.1-7.6) | 2.9 (1.5-5.4) | 2.9 (1.7-4.8) | 2.5 (1.3-4.3) | <.001 |
| Female sex | 53 (39.8) | 71 (42.5) | 95 (39.7) | 93 (39.6) | .93 |
| Race/ethnicity | |||||
| Non-Hispanic white | 49 (36.8) | 70 (41.9) | 100 (41.8) | 122 (51.9) | .20 |
| Non-Hispanic black | 29 (21.8) | 42 (25.1) | 60 (25.1) | 45 (19.1) | |
| Hispanic | 49 (36.8) | 48 (28.7) | 68 (28.5) | 61 (26.0) | |
| Other | 6 (4.5) | 7 (4.2) | 11 (4.6) | 7 (3.0) | |
| Parental history of asthma | 44 (33.1) | 49 (29.3) | 80 (33.5) | 91 (38.7) | .18 |
| Maternal smoking during pregnancy | 17 (12.8) | 21 (12.6) | 38 (15.9) | 36 (15.3) | .43 |
| C-section delivery | 47 (35.3) | 60 (35.9) | 82 (34.3) | 87 (37.0) | .60 |
| Prematurity (32-37 wk) | 26 (19.5) | 27 (16.2) | 48 (20.1) | 43 (18.3) | .78 |
| Low birth weight (<2.3 kg) | 9 (6.8) | 12 (7.2) | 13 (5.4) | 15 (6.4) | .94 |
| Sibling in the household | 98 (73.7) | 142 (85.0) | 188 (78.7) | 188 (80.0) | .11 |
| Mostly breast-fed during the first 3 mo of life | 59 (44.4) | 79 (47.3) | 88 (36.8) | 99 (42.1) | .43 |
| History of a breathing problem | 27 (20.3) | 22 (13.2) | 44 (18.4) | 37 (15.7) | .34 |
| Lifetime history of systemic antibiotic use | 52 (39.1) | 29 (17.4) | 67 (28.0) | 67 (28.5) | .001 |
| Lifetime history of corticosteroid use | 20 (15.0) | 19 (11.4) | 30 (12.6) | 28 (11.9) | .79 |
| Virus category∗ | |||||
| RSV-only | 83 (62.4) | 119 (71.3) | 176 (73.6) | 202 (86.0) | <.001 |
| RV-A | 30 (22.6) | 17 (10.2) | 31 (13.0) | 13 (5.5) | |
| RV-B | 3 (2.3) | 4 (2.4) | 4 (1.7) | 1 (0.4) | |
| RV-C | 17 (12.8) | 27 (16.2) | 28 (11.7) | 19 (8.1) | |
IQR, Interquartile range.
Data are n (%) of infants unless otherwise indicated.
∗
Of these, 48 had coinfection with a non-RSV/non-RV, which did not have statistically significant association with the microbiota profiles (P = .06).