Table E5.
Full results of the multivariable analysis on associations of RVs (exposure) with nasopharyngeal microbiota profiles (outcome) in infants hospitalized for bronchiolitis∗
| Variable | Microbiota profile |
||||||
|---|---|---|---|---|---|---|---|
|
Haemophilus-dominant (n = 133) |
Moraxella-dominant (n = 167) |
Mixed profile (n = 239) |
Streptococcus-dominant (n = 235) |
||||
| RRR (95% CI) | P value | RRR (95% CI) | P value | RRR (95% CI) | P value | RRR (95% CI) | |
| Virus category | |||||||
| RSV-only (n = 580) | Reference | Reference | Reference | Reference | |||
| RV-A (n = 91) | 5.67 (2.76-11.67) | <.001 | 2.26 (1.05-4.89) | .04 | 2.74 (1.38-5.44) | .004 | Reference |
| RV-B (n = 12) | 7.50 (0.74-76.08) | .09 | 5.72 (0.62-52.71) | .12 | 4.73 (0.52-43.04) | .17 | Reference |
| RV-C (n = 91) | 1.81 (0.86-3.81) | .12 | 2.69 (1.39-5.20) | .003 | 1.57 (0.83-2.96) | .17 | Reference |
| Age ≥ 6 mo | 2.82 (1.58-5.02) | <.001 | 2.09 (1.18-3.72) | .01 | 1.34 (0.78-2.29) | .29 | Reference |
| Female (vs male) sex | 1.08 (0.68-1.71) | .74 | 1.11 (0.73-1.69) | .63 | 1.01 (0.69-1.48) | Reference | |
| Race/ethnicity | .95 | ||||||
| Non-Hispanic white | Reference | Reference | Reference | Reference | |||
| Non-Hispanic black | 1.75 (0.96-3.22) | .07 | 1.58 (0.92-2.69) | .10 | 1.56 (0.96-2.53) | .07 | Reference |
| Hispanic | 1.94 (1.14-3.30) | .01 | 1.41 (0.86-2.33) | .17 | 1.28 (0.82-2.00) | .28 | Reference |
| Other | 2.19 (0.67-7.11) | .19 | 1.74 (0.57-5.31) | .33 | 1.98 (0.73-5.34) | .18 | Reference |
| Prematurity (32-37 wk) | 1.04 (0.59-1.83) | .90 | 0.83 (0.48-1.43) | .49 | 1.06 (0.67-1.70) | .80 | Reference |
| Sibling in the household | 0.65 (0.38-1.11) | .11 | 1.49 (0.86-2.58) | .16 | 0.89 (0.56-1.40) | .61 | Reference |
| Breast-feeding during the first 3 mo of life | 1.13 (0.70-1.84) | .62 | 1.26 (0.81-1.97) | .31 | 0.80 (0.53-1.20) | .28 | Reference |
| History of breathing problems before the index hospitalization | 0.80 (0.43-1.49) | .49 | 0.65 (0.35-1.22) | .18 | 1.05 (0.62-1.76) | .86 | Reference |
| Lifetime history of systemic antibiotic use | 1.39 (0.86-2.27) | .18 | 0.49 (0.29-0.82) | .007 | 0.94 (0.62-1.44) | .79 | Reference |
RRR, Relative rate ratio.
∗
Multinomial logistic regression model adjusting for 8 patient-level covariates. RSV-only infection was used as the reference of exposure (virus category), and Streptococcus-dominant microbiota profile was used as the reference for the outcome (nasopharyngeal microbiota profile).