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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: J Immunol. 2019 Apr 10;202(10):2843–2848. doi: 10.4049/jimmunol.1900076

Fig 2. Numerical maintenance and increased activation/effector functions of CD8 TILs in the post-septic environment.

Fig 2.

A) Experimental design. Mice received adoptive transfer of 104 Thy1.1+ naïve P14 cells before LCMV-Arm infection (2×105 PFU i.p.). 24 days later B16 cells (2×104 SQ) were injected and after 19 days surgery was performed. i.v. labeling with CD45.2 mAb was performed 3 min before tissue harvesting. B) Number of P14 cells in PBL. C) Number of vasculature-excluded (i.v.−) P14 cells in tumor samples. D) Experimental design. E) Representative histograms. % of CD8 TILs expressing F) CD69, G) PD-1, H) IFN-γ and I) Ki67. Unpaired t-tests. NS=not significant, *p<0.05, **p<0.01, ***p<0.001. Summary data from at least 3 mice per group. Data in panels B-C and E-I are representative of 2 and 3 independent experiments, respectively.