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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Dalton Trans. 2019 May 7;48(18):5987–6002. doi: 10.1039/c8dt04606a

Table 7.

Cytotoxicity and Cellular Uptake of [Co(Schiff base)(L)2]+ Complexes in A549 Lung Cancer Cells

Compound IC50 (µM) Cobalt/Protein (pg/µg) HPLC Retention Factorb
[Co(3F-salen)(NH3)2]+ >500 43.0 ± 8.4 0.21
[Co(3F-salen)(3F-BnNH2)2]+ 50 ± 16 175 ± 19 2.95
[Co(tfacen)(NH3)2]+ >500 26.7 ± 2.2 0.27
[Co(tfacen)(3F-BnNH2)2]+ 60 ± 17 697 ± 13 13.8
Co(NO3)2a >500 37 ± 2 NA
Tfacen >200 NA NA
3F-salen 97 ± 9.2 NA NA
cisplatina 5.5 ± 3.2 NA NA
a

Reported in reference 16.

b

Retention Factor = (tr – t0)/t0, where tr is the retention time of the complex and t0 is the column dead time.