Table 2. Mutational characteristics of Austin Hospital cohort divided by MET IHC.
Characteristics | Austin Hospital cohort, n [%] | ||
---|---|---|---|
Low MET (n=307) | High MET (n=119) | P | |
KRAS mutation (yes) | 42 [14] | 48 [40] | <0.001 |
EGFR mutation (yes) | 10 [3] | 16 [13] | <0.001 |
EGFR SISH copy number, median (range) | 2.3 (1.2–25.1) | 2.45 (0.0–13.6) | 0.85 |
EGFR IHC score, median (range) | 174 (0.0–300.0) | 165 (0.0–300.0) | 1.0 |
MET, mesenchyme to epithelial transition; IHC, immunohistochemical; SISH, silver-enhanced in situ hybridisation.