Table 3. Univariate and multivariable analysis of OS (n=465).
| Variables | Univariate analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P (Wald test) | HR | 95% CI | P (Wald test) | ||
| MET++ score (>50) | 0.81 | 0.65–1.01 | 0.06 | 0.87 | 0.70–1.09 | 0.24 | |
| MET GCN | 1.02 | 0.95–1.10 | 0.55 | – | – | – | |
| Sex (male) | 0.85 | 0.77–0.95 | <0.01 | 0.89 | 0.80–0.99 | 0.03 | |
| Histology (SQ vs. ADC) | 0.96 | 0.78–1.19 | 0.74 | – | – | – | |
| Histology (other vs. ADC) | 1.06 | 0.80–1.40 | 0.70 | – | – | – | |
| Stage (IB vs. IA) | 1.35 | 0.98–1.84 | 0.06 | 1.33 | 0.77–2.21 | 0.07 | |
| Stage (IIA vs. IA) | 1.92 | 1.38–2.67 | <0.01 | 1.83 | 1.00–3.20 | <0.01 | |
| Stage (IIB vs. IA) | 2.37 | 1.70–3.29 | <0.01 | 2.23 | 1.13–3.76 | <0.01 | |
| Stage (IIIA vs. IA) | 4.10 | 3.03–5.56 | <0.01 | 4.01 | 2.29–6.70 | <0.01 | |
| Stage (IIIB vs. IA) | 5.93 | 2.71–12.97 | <0.01 | 5.81 | 1.05–11.7 | <0.01 | |
| Stage (IV vs. IA) | 4.73 | 2.65–8.42 | <0.01 | 4.50 | 1.64–8.87 | <0.01 | |
OS, overall survival; MET, mesenchyme to epithelial transition; IHC, immunohistochemical; SQ, squamous cell carcinoma; ADC, adenocarcinoma.