Table 2. Validation using NGS in patients with inconsistent gene regions mutation in the paired plasma and tissue samples by ADx-ARMS.
No. | ARMS in plasma | ARMS in tumor tissue | NGS in plasma | |
---|---|---|---|---|
Mutant-type | Abundance (%) | |||
1 | 19-Del | 19-Del/T790M | 19-Del† | 1.26 |
T790M | 2.20 | |||
2 | L858R | L858R/T790M | L858R | 0.48 |
T790M | 0.27 | |||
3 | L858R | L858R/T790M | L858R | 15.37 |
T790M | 1.61 | |||
4 | 19-Del | Wild-type | 19-Del‡ | 9.45 |
†, L747_T751del; ‡, E746_A750del. ADx-ARMS, ADx-Amplification Refractory Mutation System; NGS, next-generation sequencing; 19-Del, exon 19 deletion.